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KMID : 0380420170410030133
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Journal of Prventive Veterinary Medicine
2017 Volume.41 No. 3 p.133 ~ p.136
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Single-dose acute toxicity of intraperitoneally administered Vital-Shoot containing reduced glutathione in ICR mice
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Cha Chun-Nam
Park Eun-Kee
Yoo Chang-Yeul
Kim Suk
Lee Hu-Jang
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Abstract
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This study examined the acute toxicity of Vital-Shoot containing reduced glutathione in male and female ICR mice. Mice were intraperitoneally injected the drug at dose levels of 0, 250, 500, 1,000 and 2,000 mg/kg body weight (BW) for single-dose toxicity test. There were no statistical differences in BW changes between the control and all treated groups. Based on hematological and blood biochemical analyses, the drug did not affect all parameters. In addition, markers for liver and kidney functions did not meaningfully change in all treated groups. Since there were no adverse effects from the drug in a single-dose intraperitoneal toxicity test, it was concluded that the lethal dose 50 (LD50) of Vital-Shoot is estimated to be >2,000 mg/kg BW.
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KEYWORD
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Reduced glutathione, single-dose intraperitoneal toxicity test, ICR mouse, maximum residue limit
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